Live Show

If you couldn’t tell, we’re just different.

The Big Skinny Live hits all the serious stuff — markets, money, the economy — but we don’t take ourselves too seriously. We bring on real pros who know their stuff (and aren’t afraid to say it like it is), but the vibe stays personal, laid back, and totally unfiltered. It’s smart talk without the suits and script. Just honest conversations, sharp insights, and a little sarcasm to keep it real. Catch the latest episodes below.

AI isn’t destroying jobs — it’s accelerating innovation. And investors who understand that shift may be positioned for the next major market opportunity.

In this episode, we break down why artificial intelligence is actually boosting productivity, creating new industries, and fueling a potential rebound in software stocks. We also examine the recent oil price spike, the role of geopolitical conflict in market volatility, and why history shows markets often rise after major military events.

Lou is joined by Mark Skousen of The Oxford Club and Josh Young of Bison Interests to unpack what these developments really mean for investors. Together, they discuss opportunities in defense stocks, commodities, and energy markets — along with the surprising signs that Bitcoin and cryptocurrencies may be bottoming.

You'll also learn practical strategies for navigating today’s volatile market environment — including why equal-weighted ETFs may offer smarter diversification and how the post-earnings announcement drift strategy can help investors capture sustained momentum.

If you're a retail investor looking to stay ahead of AI, commodities, and market volatility, this episode delivers the key insights you need.

- - - - - - - - - - - - - - - - - - -
Not financial advice. For entertainment only. See full Terms & Conditions on TheBigSkinny.com
- - - - - - - - - - - - - - - - - - -

New to The Big Skinny?

🖥️ Livestream Every Monday @5pm ET 
The Big Skinny LIVE cuts through Wall Street noise so Main Street can actually win — with data, charts, and zero fluff. Whether you’re a seasoned investor or just trying to figure out what the heck the Fed actually does, we break it all down in a way that makes sense — no MBA or nap required. Subscribe and never miss an episode: https://www.youtube.com/@Lou_Basenese

📩 Stay Ahead of the Market
Want the key insights from The Big Skinny delivered straight to your inbox? Get Lou’s latest market analysis in 1 headline, 1 chart and 1 investment insight in each mailing before everyone else.
Join thousands of investors staying informed — not reacting.
Sign up here: https://www.thebigskinny.com

👉 Follow Lou on Social Media:
Twitter: https://x.com/LouBasenese
LinkedIn: https://www.linkedin.com/in/lou-basenese-174821128/

--------------------------------
CHAPTERS:
--------------------------------
00:00 Introduction: Welcome to The Big Skinny with Lou Basenese
00:46 Oil Prices Breach Danger Zone and Massive Volatility
01:03 Tonight's Topics: Oil, AI Job Shock, and Special Guests
01:36 Guest Josh Young of Bison Insights on the Energy Market
02:17 Manifesto: Be Humble in the Markets
03:20 AI Fright Reaching Finance, According to Pitchbook
04:30 Contrarian Viewpoint: Tech Has Never Caused a Job Apocalypse
05:31 Tech CEO of Whoop: Companies are Adding Jobs, Not AI Layoffs
07:20 Berkeley Study on AI Workers Shows Increased Productivity
08:37 Money Chart of the Week: New Business Applications Post-AI Launch
09:20 Investment Insight: Equal S&P Software and Services ETF
10:37 Energy ETF (XLE) Performance as a Turnaround Example
11:30 Lou Basenese's Favorite Sectors: Energy, Biotech, and Small Caps
12:39 Dr. Mark Skousen Joins the Show: Adam Smith Day and Market Volatility
13:36 Oil Price Spike Fueled by Israel Bombing Iranian Fuel Depots
15:30 Dr. Skousen Agrees AI Will Create More Jobs Than It Loses
16:40 Dr. Skousen: Gold and Silver Bug, Early Adopter of AI and Bitcoin
20:15 Dr. Skousen's Favorite Stocks: Amgen (Biotech) and Defense Stocks
21:50 Where to Find Dr. Mark Skousen's Research
23:31 Dr. Skousen's Insights on Copper (Southern Copper) and Cryptocurrencies (Amplify Fund BLK)
25:10 Segment on Energy and Oil Volatility with Josh Young
26:14 Oil Price Spikes (70-80%) Lead to Recession
26:40 Josh Young of Bison Insights on Oil Market Volatility
27:23 Josh Young's Day: Oil Spiking Due to US/Israel Bombing Fuel Depots
28:43 Oil Supply Disruptions and Shut-In Barrels Will Take Months to Ramp Up
30:10 Josh Young is an Oil and Gas Equities Investor, Not a Commodity Investor
31:25 Trump Administration's Effort to Suppress Oil Price
32:29 Nixon in the 1970s: Aggressive Price Suppression and High Oil/Gas Equity Returns
33:10 Josh Young Sees Opportunity in Low Valuation Companies with a Catalyst
34:37 How to Find Josh Young's Newsletter (Bison Insights)
38:43 Headlines and Head Scratchers Segment
41:47 Volatility is the New Norm in Individual Investments/Sectors
42:17 "Oil Oops": Prediction on Oil at $100 and Recession
44:32 Should You Hide in Times of Market Volatility? Buffettisms
46:52 Predictions Market in the Headlines: Lawsuits and Payouts
48:13 Dow Intraday Declines and Market Volatility
49:38 Safest Play for Risk-Averse Investors: Diversified ETFs
50:00 Investment Strategy: 70-80% in ETFs, 20-30% Speculative Stocks
52:57 Fed Needs to Cut Interest Rates and Kevin Walsh is the Key
54:23 Divergence: Semiconductors vs. Software
55:18 Post-Earnings Announcement Drift (PEAD) Phenomenon

AI isn’t destroying jobs — it’s accelerating innovation. And investors who understand that shift may be positioned for the next major market opportunity.

In this episode, we break down why artificial intelligence is actually boosting productivity, creating new industries, and fueling a potential rebound in software stocks. We also examine the recent oil price spike, the role of geopolitical conflict in market volatility, and why history shows markets often rise after major military events.

Lou is joined by Mark Skousen of The Oxford Club and Josh Young of Bison Interests to unpack what these developments really mean for investors. Together, they discuss opportunities in defense stocks, commodities, and energy markets — along with the surprising signs that Bitcoin and cryptocurrencies may be bottoming.

You'll also learn practical strategies for navigating today’s volatile market environment — including why equal-weighted ETFs may offer smarter diversification and how the post-earnings announcement drift strategy can help investors capture sustained momentum.

If you're a retail investor looking to stay ahead of AI, commodities, and market volatility, this episode delivers the key insights you need.

- - - - - - - - - - - - - - - - - - -
Not financial advice. For entertainment only. See full Terms & Conditions on TheBigSkinny.com
- - - - - - - - - - - - - - - - - - -

New to The Big Skinny?

🖥️ Livestream Every Monday @5pm ET
The Big Skinny LIVE cuts through Wall Street noise so Main Street can actually win — with data, charts, and zero fluff. Whether you’re a seasoned investor or just trying to figure out what the heck the Fed actually does, we break it all down in a way that makes sense — no MBA or nap required. Subscribe and never miss an episode: https://www.youtube.com/@Lou_Basenese

📩 Stay Ahead of the Market
Want the key insights from The Big Skinny delivered straight to your inbox? Get Lou’s latest market analysis in 1 headline, 1 chart and 1 investment insight in each mailing before everyone else.
Join thousands of investors staying informed — not reacting.
Sign up here: https://www.thebigskinny.com

👉 Follow Lou on Social Media:
Twitter: https://x.com/LouBasenese
LinkedIn: https://www.linkedin.com/in/lou-basenese-174821128/

--------------------------------
CHAPTERS:
--------------------------------
00:00 Introduction: Welcome to The Big Skinny with Lou Basenese
00:46 Oil Prices Breach Danger Zone and Massive Volatility
01:03 Tonight's Topics: Oil, AI Job Shock, and Special Guests
01:36 Guest Josh Young of Bison Insights on the Energy Market
02:17 Manifesto: Be Humble in the Markets
03:20 AI Fright Reaching Finance, According to Pitchbook
04:30 Contrarian Viewpoint: Tech Has Never Caused a Job Apocalypse
05:31 Tech CEO of Whoop: Companies are Adding Jobs, Not AI Layoffs
07:20 Berkeley Study on AI Workers Shows Increased Productivity
08:37 Money Chart of the Week: New Business Applications Post-AI Launch
09:20 Investment Insight: Equal S&P Software and Services ETF
10:37 Energy ETF (XLE) Performance as a Turnaround Example
11:30 Lou Basenese's Favorite Sectors: Energy, Biotech, and Small Caps
12:39 Dr. Mark Skousen Joins the Show: Adam Smith Day and Market Volatility
13:36 Oil Price Spike Fueled by Israel Bombing Iranian Fuel Depots
15:30 Dr. Skousen Agrees AI Will Create More Jobs Than It Loses
16:40 Dr. Skousen: Gold and Silver Bug, Early Adopter of AI and Bitcoin
20:15 Dr. Skousen's Favorite Stocks: Amgen (Biotech) and Defense Stocks
21:50 Where to Find Dr. Mark Skousen's Research
23:31 Dr. Skousen's Insights on Copper (Southern Copper) and Cryptocurrencies (Amplify Fund BLK)
25:10 Segment on Energy and Oil Volatility with Josh Young
26:14 Oil Price Spikes (70-80%) Lead to Recession
26:40 Josh Young of Bison Insights on Oil Market Volatility
27:23 Josh Young's Day: Oil Spiking Due to US/Israel Bombing Fuel Depots
28:43 Oil Supply Disruptions and Shut-In Barrels Will Take Months to Ramp Up
30:10 Josh Young is an Oil and Gas Equities Investor, Not a Commodity Investor
31:25 Trump Administration's Effort to Suppress Oil Price
32:29 Nixon in the 1970s: Aggressive Price Suppression and High Oil/Gas Equity Returns
33:10 Josh Young Sees Opportunity in Low Valuation Companies with a Catalyst
34:37 How to Find Josh Young's Newsletter (Bison Insights)
38:43 Headlines and Head Scratchers Segment
41:47 Volatility is the New Norm in Individual Investments/Sectors
42:17 "Oil Oops": Prediction on Oil at $100 and Recession
44:32 Should You Hide in Times of Market Volatility? Buffettisms
46:52 Predictions Market in the Headlines: Lawsuits and Payouts
48:13 Dow Intraday Declines and Market Volatility
49:38 Safest Play for Risk-Averse Investors: Diversified ETFs
50:00 Investment Strategy: 70-80% in ETFs, 20-30% Speculative Stocks
52:57 Fed Needs to Cut Interest Rates and Kevin Walsh is the Key
54:23 Divergence: Semiconductors vs. Software
55:18 Post-Earnings Announcement Drift (PEAD) Phenomenon

YouTube Video UExLT2djMjVoa0d1dENhRkZhSkJpRXhFMTZiWUxtTXJ0dy45NkVENTkxRDdCQUFBMDY4

Oil Shock, AI Job Jitters & the Economy: What Happens Next?

Tue Mar 10th, 2026

This week on The Big Skinny, Lou Basenese breaks down Nvidia’s latest blockbuster earnings report and asks the question investors really care about: what happens next?
With earnings accelerating and free cash flow surging, the AI thesis remains intact. But markets don’t move on headlines alone – they move on positioning.

Lou is joined by Eddie Ghabour of Key Advisors Wealth Management and Dale Smothers of RDS Wealth to dig into whether we’re witnessing the start of a meaningful rotation – from mega-cap AI leaders into small caps, cyclicals, and broader market participation.

Plus in Headlines & Headscratchers, Lou and Dodd tackle Novo Nordisk’s strategic conundrum, the surge in global bull market breadth, the sub-3% mortgage “glitch,” and what insider trading in prediction markets says about speculation in 2026.

No fluff. No fear-mongering. Just a data-driven look at where risk and opportunity really lie.

- - - - - - - - - - - - - - - - - - -
Not financial advice. For entertainment only. See full Terms & Conditions on TheBigSkinny.com
- - - - - - - - - - - - - - - - - - -

New to The Big Skinny?

🖥️ Livestream Every Monday @5pm ET 
The Big Skinny LIVE cuts through Wall Street noise so Main Street can actually win — with data, charts, and zero fluff. Whether you’re a seasoned investor or just trying to figure out what the heck the Fed actually does, we break it all down in a way that makes sense — no MBA or nap required. Subscribe and never miss an episode: https://www.youtube.com/@Lou_Basenese

👉 Follow Lou on Social Media:
Twitter: https://x.com/LouBasenese
LinkedIn: https://www.linkedin.com/in/lou-basenese-174821128/

--------------------------------
CHAPTERS:
--------------------------------
01:14 Intro: Big Tech on Trial
01:51 Segment Guest Introductions
03:19 The Rundown: Nvidia and AI Bubble
04:07 Nvidia Earnings and Market Reaction
05:43 AI Cash Burn and Investor Tension
08:53 Investment Takeaway: Keep Buying Nvidia
10:52 Interview with Eddie Gabbor: Tech, Rotation, and Small Caps
12:17 Eddie Ghabour: Market Technicals
14:37 Eddie Ghabour: Small Cap Conviction
17:48 Eddie Ghabour: Energy and Housing
21:44 Interview with Dale Smothers: Market, Fed, and Risk Management
22:22 Dale Smothers: Nvidia and Large Cap Opportunities
23:41 Dale Smothers: Equal Weight S&P 500 RSP
25:42 Dale Smothers: Oil and Inflation Concerns
27:37 Dale Smothers: Fed Policy and Fixed Income Allocation
29:55 Dale Smothers: Dividend Equities and Options
31:53 Dale Smothers: Speculative Assets Applied Digital
35:33 Headlines and Head Scratchers: AI and Jobs
38:23 Headlines and Head Scratchers: Novo Nordisk NVO
40:20 Headlines and Head Scratchers: Retail Trading Volume
42:50 Headlines and Head Scratchers: Global Bull Market
44:18 Headlines and Head Scratchers: Rate Relief and Housing
46:01 Headlines and Head Scratchers: Prediction Markets Busted Bets
47:43 2026 Prediction Bingo Card Update
50:38 Closing

This week on The Big Skinny, Lou Basenese breaks down Nvidia’s latest blockbuster earnings report and asks the question investors really care about: what happens next?
With earnings accelerating and free cash flow surging, the AI thesis remains intact. But markets don’t move on headlines alone – they move on positioning.

Lou is joined by Eddie Ghabour of Key Advisors Wealth Management and Dale Smothers of RDS Wealth to dig into whether we’re witnessing the start of a meaningful rotation – from mega-cap AI leaders into small caps, cyclicals, and broader market participation.

Plus in Headlines & Headscratchers, Lou and Dodd tackle Novo Nordisk’s strategic conundrum, the surge in global bull market breadth, the sub-3% mortgage “glitch,” and what insider trading in prediction markets says about speculation in 2026.

No fluff. No fear-mongering. Just a data-driven look at where risk and opportunity really lie.

- - - - - - - - - - - - - - - - - - -
Not financial advice. For entertainment only. See full Terms & Conditions on TheBigSkinny.com
- - - - - - - - - - - - - - - - - - -

New to The Big Skinny?

🖥️ Livestream Every Monday @5pm ET
The Big Skinny LIVE cuts through Wall Street noise so Main Street can actually win — with data, charts, and zero fluff. Whether you’re a seasoned investor or just trying to figure out what the heck the Fed actually does, we break it all down in a way that makes sense — no MBA or nap required. Subscribe and never miss an episode: https://www.youtube.com/@Lou_Basenese

👉 Follow Lou on Social Media:
Twitter: https://x.com/LouBasenese
LinkedIn: https://www.linkedin.com/in/lou-basenese-174821128/

--------------------------------
CHAPTERS:
--------------------------------
01:14 Intro: Big Tech on Trial
01:51 Segment Guest Introductions
03:19 The Rundown: Nvidia and AI Bubble
04:07 Nvidia Earnings and Market Reaction
05:43 AI Cash Burn and Investor Tension
08:53 Investment Takeaway: Keep Buying Nvidia
10:52 Interview with Eddie Gabbor: Tech, Rotation, and Small Caps
12:17 Eddie Ghabour: Market Technicals
14:37 Eddie Ghabour: Small Cap Conviction
17:48 Eddie Ghabour: Energy and Housing
21:44 Interview with Dale Smothers: Market, Fed, and Risk Management
22:22 Dale Smothers: Nvidia and Large Cap Opportunities
23:41 Dale Smothers: Equal Weight S&P 500 RSP
25:42 Dale Smothers: Oil and Inflation Concerns
27:37 Dale Smothers: Fed Policy and Fixed Income Allocation
29:55 Dale Smothers: Dividend Equities and Options
31:53 Dale Smothers: Speculative Assets Applied Digital
35:33 Headlines and Head Scratchers: AI and Jobs
38:23 Headlines and Head Scratchers: Novo Nordisk NVO
40:20 Headlines and Head Scratchers: Retail Trading Volume
42:50 Headlines and Head Scratchers: Global Bull Market
44:18 Headlines and Head Scratchers: Rate Relief and Housing
46:01 Headlines and Head Scratchers: Prediction Markets Busted Bets
47:43 2026 Prediction Bingo Card Update
50:38 Closing

YouTube Video UExLT2djMjVoa0d1dENhRkZhSkJpRXhFMTZiWUxtTXJ0dy4zQzFBN0RGNzNFREFCMjBE

NVDA Delivers. Now What? Rotation, Risk & Reality

Tue Mar 3rd, 2026

This week on The Big Skinny, Lou Basenese goes head-to-head with Futurum Group's CEO Daniel Newman in a special debate episode sparked by a viral tweet defending Hims & Hers Health, Inc. (HIMS) compounding Novo Nordisk’s (NVO) leading drug. Is HIMS a legitimate healthcare disruptor – or underestimating the power of Big Pharma and regulatory risk? Lou and Dan break down what this controversy means for investors, the real economics behind GLP-1 drugs, and whether disruption always wins in healthcare.

Then Lou widens the lens to the broader market, tackling the state of the AI trade and the recent wave of sharp software stock selloffs. Are these cracks forming beneath the surface — or healthy resets in a long-term bull cycle? No fluff. No fear-mongering. Just a data-driven debate about where risk and opportunity really lie.

- - - - - - - - - - - - - - - - - - -
Not financial advice. For entertainment only. See full Terms & Conditions on TheBigSkinny.com
- - - - - - - - - - - - - - - - - - -

New to The Big Skinny?

🖥️ Livestream Every Monday @5pm ET 
The Big Skinny LIVE cuts through Wall Street noise so Main Street can actually win — with data, charts, and zero fluff. Whether you’re a seasoned investor or just trying to figure out what the heck the Fed actually does, we break it all down in a way that makes sense — no MBA or nap required. Subscribe and never miss an episode: https://www.youtube.com/@Lou_Basenese

👉 Follow Lou on Social Media:
Twitter: https://x.com/LouBasenese
LinkedIn: https://www.linkedin.com/in/lou-basenese-174821128/

- - - - - - - - - - - - - - - - - - -
CHAPTERS
- - - - - - - - - - - - - - - - - - -
00:00 Introduction – The GLP-1 Pharma Battle Begins
02:15 What Started the HIMS vs Novo Nordisk Debate
05:30 IP Protection vs Personalized Medicine
09:10 Is HIMS Legally Protected Under Compounding Rules?
13:20 The Dosing Problem: Why GLP-1 Personalization Matters
18:00 Semaglutide vs Tirzepatide vs Retatrutide Explained
22:10 Why Viking Therapeutics Could Be a Game Changer
25:30 Investment Takeaway: HIMS vs Eli Lilly vs Novo Nordisk
29:00 AI Bubble or AI Revolution?
32:40 Market Rotation: Tech No Longer Driving the Bull Market
35:10 Energy Outperforming Tech – What That Means
37:20 Software Selloff: Buy the Dip or Catching a Falling Knife?
39:15 Apple AI Strategy – Smart Move or Behind the Curve?
41:30 Final Thoughts & What to Watch Next Week

This week on The Big Skinny, Lou Basenese goes head-to-head with Futurum Group's CEO Daniel Newman in a special debate episode sparked by a viral tweet defending Hims & Hers Health, Inc. (HIMS) compounding Novo Nordisk’s (NVO) leading drug. Is HIMS a legitimate healthcare disruptor – or underestimating the power of Big Pharma and regulatory risk? Lou and Dan break down what this controversy means for investors, the real economics behind GLP-1 drugs, and whether disruption always wins in healthcare.

Then Lou widens the lens to the broader market, tackling the state of the AI trade and the recent wave of sharp software stock selloffs. Are these cracks forming beneath the surface — or healthy resets in a long-term bull cycle? No fluff. No fear-mongering. Just a data-driven debate about where risk and opportunity really lie.

- - - - - - - - - - - - - - - - - - -
Not financial advice. For entertainment only. See full Terms & Conditions on TheBigSkinny.com
- - - - - - - - - - - - - - - - - - -

New to The Big Skinny?

🖥️ Livestream Every Monday @5pm ET
The Big Skinny LIVE cuts through Wall Street noise so Main Street can actually win — with data, charts, and zero fluff. Whether you’re a seasoned investor or just trying to figure out what the heck the Fed actually does, we break it all down in a way that makes sense — no MBA or nap required. Subscribe and never miss an episode: https://www.youtube.com/@Lou_Basenese

👉 Follow Lou on Social Media:
Twitter: https://x.com/LouBasenese
LinkedIn: https://www.linkedin.com/in/lou-basenese-174821128/

- - - - - - - - - - - - - - - - - - -
CHAPTERS
- - - - - - - - - - - - - - - - - - -
00:00 Introduction – The GLP-1 Pharma Battle Begins
02:15 What Started the HIMS vs Novo Nordisk Debate
05:30 IP Protection vs Personalized Medicine
09:10 Is HIMS Legally Protected Under Compounding Rules?
13:20 The Dosing Problem: Why GLP-1 Personalization Matters
18:00 Semaglutide vs Tirzepatide vs Retatrutide Explained
22:10 Why Viking Therapeutics Could Be a Game Changer
25:30 Investment Takeaway: HIMS vs Eli Lilly vs Novo Nordisk
29:00 AI Bubble or AI Revolution?
32:40 Market Rotation: Tech No Longer Driving the Bull Market
35:10 Energy Outperforming Tech – What That Means
37:20 Software Selloff: Buy the Dip or Catching a Falling Knife?
39:15 Apple AI Strategy – Smart Move or Behind the Curve?
41:30 Final Thoughts & What to Watch Next Week

YouTube Video UExLT2djMjVoa0d1dENhRkZhSkJpRXhFMTZiWUxtTXJ0dy5GNDg1Njc1QzZERjlFRjE5

Pharma Battle: NVO vs. HIMS – Who’s Right?

Sat Feb 14th, 2026

This week on The Big Skinny, Lou Basenese dives into biotech’s comeback. After years of pain, the sector is showing clear signs of revival — from renewed IPO activity and M&A interest to improving stock price performance.

Lou is joined by Jonathan Faison, who breaks down how to invest in biotech without needing a PhD. He explains how retail investors can approach the sector systematically, focusing on data-driven winners instead of binary gambles.

Later in the show, Jon Erlichman joins Lou to add broader market context — from capital flows and sentiment shifts to how biotech fits into the evolving 2026 investment landscape.

Finally, Lou and Dodd wrap with rapid-fire takes on prediction markets, the SaaS shakeout, Fed missteps, and why market leadership is broadening in 2026.

👇 Jump in the comments, ask questions during the live stream, and let us know which sector you’re watching most.

Don’t forget to subscribe for more straight-talk market insights on The Big Skinny.

- - - - - - - - - - - - - - - - - - -
Not financial advice. For entertainment only. See full Terms & Conditions on TheBigSkinny.com
- - - - - - - - - - - - - - - - - - -

New to The Big Skinny?

🖥️ Livestream Every Monday @5pm ET 
The Big Skinny LIVE cuts through Wall Street noise so Main Street can actually win — with data, charts, and zero fluff. Whether you’re a seasoned investor or just trying to figure out what the heck the Fed actually does, we break it all down in a way that makes sense — no MBA or nap required. Subscribe and never miss an episode: https://www.youtube.com/@Lou_Basenese

👉 Follow Lou on Social Media:
Twitter: https://x.com/LouBasenese
LinkedIn: https://www.linkedin.com/in/lou-basenese-174821128/

- - - - - - - - - - - - - - - - - - -
CHAPTERS
- - - - - - - - - - - - - - - - - - -
00:00 Welcome and Show Overview
01:05 Intro: Biotech is Back & SAS Apocalypse?
03:21 Rundown: The Only Headline/Chart/Idea You Need
04:15 Why the Biotech Sector Is Unapologetically Back
06:05 Biotech Volatility & Why We're Not at a Top Yet
06:56 The $180 Billion Big Pharma Patent Cliff
08:06 M&A Wave: Why Big Pharma Must Acquire Biotech
09:44 The Best Way to Invest in Biotech (The XBI ETF)
11:26 Follow The Big Skinny on Socials
12:02 Interview: Jonathan Faison's Biotech Strategy
13:48 Faison's Crushing Past Stock Picks (SNDX, LQDA)
16:41 From Self-Taught to Biotech Pro: Tips for New Investors
18:38 Why Commercial-Stage Biotech is the "Sleep Well at Night" Edge
20:00 Jonathan Faison's "Clear Path to Market" Filter
21:06 Faison's Disciplined Investing: Trading 2–4 Days a Month
23:31 Jonathan Faison's New Top Pick: Kura Therapeutics (KURA)
27:26 Faison's Exit Strategy: When to Sell a Losing Stock
28:44 The ROI Biotech Community
30:55 AI-Generated Super Bowl Ads & Job Threats
32:47 Is the SAS Apocalypse Overblown?
34:49 Why Software Companies Will Integrate AI to Thrive (Salesforce, ServiceNow)
37:42 John Erlickman's Favorite AI Agent
39:22 Alphabet's AI Comeback: A Warning for Tech Skeptics
39:56 SpaceX IPO: Bull Case vs. Flame-Out Prediction
41:43 Starlink and Reusable Rockets: Fueling the Space Economy
43:35 Elon Musk Shifts Focus to the Moon: A Smart Move?
46:26 The Nvidia Effect: SpaceX Could Create Millionaires
47:06 Amazon & Walmart Valuation Discussion
50:04 The Tesla-SpaceX Merger Idea
51:10 Where to Follow John Erlickman
52:01 Teaser: Phil Rosen Interview (Opening Bell Daily News)
54:10 Headlines & Head Scratchers: Prediction Markets Implode
57:36 Data Check: Software Job Postings Down—Threat or Profit Margin Booster?

This week on The Big Skinny, Lou Basenese dives into biotech’s comeback. After years of pain, the sector is showing clear signs of revival — from renewed IPO activity and M&A interest to improving stock price performance.

Lou is joined by Jonathan Faison, who breaks down how to invest in biotech without needing a PhD. He explains how retail investors can approach the sector systematically, focusing on data-driven winners instead of binary gambles.

Later in the show, Jon Erlichman joins Lou to add broader market context — from capital flows and sentiment shifts to how biotech fits into the evolving 2026 investment landscape.

Finally, Lou and Dodd wrap with rapid-fire takes on prediction markets, the SaaS shakeout, Fed missteps, and why market leadership is broadening in 2026.

👇 Jump in the comments, ask questions during the live stream, and let us know which sector you’re watching most.

Don’t forget to subscribe for more straight-talk market insights on The Big Skinny.

- - - - - - - - - - - - - - - - - - -
Not financial advice. For entertainment only. See full Terms & Conditions on TheBigSkinny.com
- - - - - - - - - - - - - - - - - - -

New to The Big Skinny?

🖥️ Livestream Every Monday @5pm ET
The Big Skinny LIVE cuts through Wall Street noise so Main Street can actually win — with data, charts, and zero fluff. Whether you’re a seasoned investor or just trying to figure out what the heck the Fed actually does, we break it all down in a way that makes sense — no MBA or nap required. Subscribe and never miss an episode: https://www.youtube.com/@Lou_Basenese

👉 Follow Lou on Social Media:
Twitter: https://x.com/LouBasenese
LinkedIn: https://www.linkedin.com/in/lou-basenese-174821128/

- - - - - - - - - - - - - - - - - - -
CHAPTERS
- - - - - - - - - - - - - - - - - - -
00:00 Introduction
02:10 What The Big Skinny Gets Right (And Media Gets Wrong)
05:05 The Rundown: Ignore This Headline
08:20 The One Chart Investors Should Watch
12:10 The Key Investment Idea Right Now
15:30 Biotech Is Back: Why XBI Is Up Over 70%
20:40 Big Pharma’s Patent Cliff & Why Biotech Wins
26:30 How New Investors Should Play Biotech
30:15 Jonathan Faison Joins: Biotech Picks & Process
35:10 Reviewing Past Winners: SNDX & LQDA
39:45 How to Think About Risk in Biotech
44:20 Commercial vs. Clinical Stage Investing
48:50 Kura Therapeutics (KURA) Breakdown
53:40 How to Know When to Sell: “Portfolio Cage Match”
57:30 Building an Edge & Avoiding FOMO Trading
1:01:40 Big Tech Sell-Offs & the “SaaS Apocalypse”
1:06:10 AI, Software Valuations & Where Opportunity Is
1:11:30 ServiceNow, Salesforce & CrowdStrike
1:16:20 SpaceX IPO: Why It Could Be a Capital Disaster
1:22:10 Starlink, Satellites & the Telecom Disruption
1:27:00 Final Thoughts & Market Takeaways

YouTube Video UExLT2djMjVoa0d1dENhRkZhSkJpRXhFMTZiWUxtTXJ0dy4xOTEzQzhBQzU3MDNDNjcz

Biotech Is Back: How to Invest Without Getting Burned

Tue Feb 10th, 2026

The next major investing wave is already forming — most people just aren’t paying attention yet.

Live from Nicaragua, Lou Basenese sits down with top analyst Matt McCall, founder of Nxt Wave Research, to break down what’s really happening in crypto, Bitcoin, meme coins, biotech rebounds, critical minerals, and the next phase of AI investing. This is a wide-ranging, no-hype conversation focused on where real opportunities may emerge next, and how smart investors are positioning ahead of the crowd.

Whether you’re watching crypto volatility, waiting on biotech to rebound, or wondering where AI goes after the hype, this episode connects the dots across markets and themes that could shape the next cycle.

👇 Jump in the comments, ask questions during the live stream, and let us know which sector you’re watching most.

Don’t forget to subscribe for more straight-talk market insights on The Big Skinny.

- - - - - - - - - - - - - - - - - - -
Not financial advice. For entertainment only. See full Terms & Conditions on TheBigSkinny.com
- - - - - - - - - - - - - - - - - - -

New to The Big Skinny?

🖥️ Livestream Every Monday @5pm ET 
The Big Skinny LIVE cuts through Wall Street noise so Main Street can actually win — with data, charts, and zero fluff. Whether you’re a seasoned investor or just trying to figure out what the heck the Fed actually does, we break it all down in a way that makes sense — no MBA or nap required. Subscribe and never miss an episode: https://www.youtube.com/@Lou_Basenese

👉 Follow Lou on Social Media:
Twitter: https://x.com/LouBasenese
LinkedIn: https://www.linkedin.com/in/lou-basenese-174821128/

- - - - - - - - - - - - - - - - - - -
CHAPTERS
- - - - - - - - - - - - - - - - - - -
00:00 Introduction
02:15 Live From Nicaragua + Welcome to The Big Skinny
05:10 Meet Matt McCall: NextWave Research & Market Outlook
09:30 Bitcoin, Crypto Cycles & Market Psychology
15:40 Meme Coins: Speculation vs. Opportunity
21:55 Is a Biotech Rebound Finally Coming?
28:10 Critical Minerals & the Global Supply Race
34:45 The Next Wave of AI Investing Plays
41:20 How to Think About Risk in Volatile Markets
47:30 What Smart Money Is Watching Right Now
52:10 Final Thoughts & Viewer Questions

The next major investing wave is already forming — most people just aren’t paying attention yet.

Live from Nicaragua, Lou Basenese sits down with top analyst Matt McCall, founder of Nxt Wave Research, to break down what’s really happening in crypto, Bitcoin, meme coins, biotech rebounds, critical minerals, and the next phase of AI investing. This is a wide-ranging, no-hype conversation focused on where real opportunities may emerge next, and how smart investors are positioning ahead of the crowd.

Whether you’re watching crypto volatility, waiting on biotech to rebound, or wondering where AI goes after the hype, this episode connects the dots across markets and themes that could shape the next cycle.

👇 Jump in the comments, ask questions during the live stream, and let us know which sector you’re watching most.

Don’t forget to subscribe for more straight-talk market insights on The Big Skinny.

- - - - - - - - - - - - - - - - - - -
Not financial advice. For entertainment only. See full Terms & Conditions on TheBigSkinny.com
- - - - - - - - - - - - - - - - - - -

New to The Big Skinny?

🖥️ Livestream Every Monday @5pm ET
The Big Skinny LIVE cuts through Wall Street noise so Main Street can actually win — with data, charts, and zero fluff. Whether you’re a seasoned investor or just trying to figure out what the heck the Fed actually does, we break it all down in a way that makes sense — no MBA or nap required. Subscribe and never miss an episode: https://www.youtube.com/@Lou_Basenese

👉 Follow Lou on Social Media:
Twitter: https://x.com/LouBasenese
LinkedIn: https://www.linkedin.com/in/lou-basenese-174821128/

- - - - - - - - - - - - - - - - - - -
CHAPTERS
- - - - - - - - - - - - - - - - - - -
00:00 Introduction
02:15 Live From Nicaragua + Welcome to The Big Skinny
05:10 Meet Matt McCall: NextWave Research & Market Outlook
09:30 Bitcoin, Crypto Cycles & Market Psychology
15:40 Meme Coins: Speculation vs. Opportunity
21:55 Is a Biotech Rebound Finally Coming?
28:10 Critical Minerals & the Global Supply Race
34:45 The Next Wave of AI Investing Plays
41:20 How to Think About Risk in Volatile Markets
47:30 What Smart Money Is Watching Right Now
52:10 Final Thoughts & Viewer Questions

YouTube Video UExLT2djMjVoa0d1dENhRkZhSkJpRXhFMTZiWUxtTXJ0dy5BRjJDODk5REM0NjkzMUIy

Bitcoin, Biotech & Beyond: Finding Opportunity After the Crypto Crash

Tue Feb 3rd, 2026

The bull market is "getting very hard to find bears to talk to", but what's the biggest risk to look out for in 2026? Find out Phil Rosen's bold predictions for the year ahead.

In this episode of The Big Skinny with Lou Basenese, we sit down with Phil Rosen, co-founder of Opening Bell Daily and host of The Full Signal, to get a bird's eye view of the market. Phil shares the consensus view from Wall Street experts, offering his insights on where the market is headed. He discusses why AI is the theme to go all-in on and why the bubble narrative is a myth. 

You'll learn:
• Why the speaker believes the S&P 500 will outperform Wall Street's consensus 10% gain.
• The biggest "black swan" risk that could trigger a panic in the AI trade.
• The prediction for multiple Fed rate cuts this year, contrasting the one-cut expectation from others.
• The one chart to watch: the performance of the "MAG 7" compared to the S&P 500.
• Why the AI growth trend is durable and the next derivatives play in the market.
• How gold and Bitcoin compare as assets, with a focus on their long-term performance.
• How Phil Rosen synthesizes market information to create the defining story of the day.

Phil believes that if the AI surge is a bubble, it's the "first bubble in history where supply cannot keep up with demand". Don't miss this deep dive into 2026 market predictions and the investment landscape for the year.

Sign up for Phil Rosen's free newsletter, Opening Bell Daily, and check out the Best Ideas Club paid service at Openingbelldailynews.com.

Not financial advice. For entertainment only. See full Terms & Conditions on TheBigSkinny.com

- - - - - - - - - - - - - - - - - - -

New to The Big Skinny?

🖥️ Livestream Every Monday @5pm ET 
The Big Skinny LIVE cuts through Wall Street noise so Main Street can actually win — with data, charts, and zero fluff. Whether you’re a seasoned investor or just trying to figure out what the heck the Fed actually does, we break it all down in a way that makes sense — no MBA or nap required. Subscribe and never miss an episode: https://www.youtube.com/@Lou_Basenese

👉 Follow Lou on Social Media:
Twitter: https://x.com/LouBasenese
LinkedIn: https://www.linkedin.com/in/lou-basenese-174821128/

———————
Chapters
———————
00:00 Introduction
00:28 Welcome Phil Rosen of Opening Bell Daily
01:06 Why It's Hard to Find Market Bears
01:50 Rapid Fire: 2026 Market Surprise
02:47 The Biggest Risk to the AI Trade
03:45 Fed Independence and Rate Cut Prediction
05:08 The One Chart to Watch for 2026
06:13 Why Nvidia and Google Will Keep Winning
07:00 The Myth Retail Investors Fall For
08:35 The Durability of AI Growth Trend
10:20 Bear Case: Debt Spending and Circular Financing
11:34 Next Wave of AI: The Hardware Play
12:47 Viewpoint on Big IPOs (SpaceX, Anthropic)
13:54 Is the Bull Market Broadening Out?
15:11 Tech Exposure: Is 38% of S&P 500 a Concern?
16:15 Gold vs. Bitcoin: The Debasement Trade
17:35 Bitcoin's Surprising Underperformance in 2025
19:43 Should You Own Gold and Bitcoin?
20:38 Phil Rosen's Process: Signal from the Noise
22:03 Opening Bell Daily and Best Ideas Club
24:02 Favorite New York City Spot (A Hard Question!)

The bull market is "getting very hard to find bears to talk to", but what's the biggest risk to look out for in 2026? Find out Phil Rosen's bold predictions for the year ahead.

In this episode of The Big Skinny with Lou Basenese, we sit down with Phil Rosen, co-founder of Opening Bell Daily and host of The Full Signal, to get a bird's eye view of the market. Phil shares the consensus view from Wall Street experts, offering his insights on where the market is headed. He discusses why AI is the theme to go all-in on and why the bubble narrative is a myth.

You'll learn:
• Why the speaker believes the S&P 500 will outperform Wall Street's consensus 10% gain.
• The biggest "black swan" risk that could trigger a panic in the AI trade.
• The prediction for multiple Fed rate cuts this year, contrasting the one-cut expectation from others.
• The one chart to watch: the performance of the "MAG 7" compared to the S&P 500.
• Why the AI growth trend is durable and the next derivatives play in the market.
• How gold and Bitcoin compare as assets, with a focus on their long-term performance.
• How Phil Rosen synthesizes market information to create the defining story of the day.

Phil believes that if the AI surge is a bubble, it's the "first bubble in history where supply cannot keep up with demand". Don't miss this deep dive into 2026 market predictions and the investment landscape for the year.

Sign up for Phil Rosen's free newsletter, Opening Bell Daily, and check out the Best Ideas Club paid service at Openingbelldailynews.com.

Not financial advice. For entertainment only. See full Terms & Conditions on TheBigSkinny.com

- - - - - - - - - - - - - - - - - - -

New to The Big Skinny?

🖥️ Livestream Every Monday @5pm ET
The Big Skinny LIVE cuts through Wall Street noise so Main Street can actually win — with data, charts, and zero fluff. Whether you’re a seasoned investor or just trying to figure out what the heck the Fed actually does, we break it all down in a way that makes sense — no MBA or nap required. Subscribe and never miss an episode: https://www.youtube.com/@Lou_Basenese

👉 Follow Lou on Social Media:
Twitter: https://x.com/LouBasenese
LinkedIn: https://www.linkedin.com/in/lou-basenese-174821128/

———————
Chapters
———————
00:00 Introduction
00:28 Welcome Phil Rosen of Opening Bell Daily
01:06 Why It's Hard to Find Market Bears
01:50 Rapid Fire: 2026 Market Surprise
02:47 The Biggest Risk to the AI Trade
03:45 Fed Independence and Rate Cut Prediction
05:08 The One Chart to Watch for 2026
06:13 Why Nvidia and Google Will Keep Winning
07:00 The Myth Retail Investors Fall For
08:35 The Durability of AI Growth Trend
10:20 Bear Case: Debt Spending and Circular Financing
11:34 Next Wave of AI: The Hardware Play
12:47 Viewpoint on Big IPOs (SpaceX, Anthropic)
13:54 Is the Bull Market Broadening Out?
15:11 Tech Exposure: Is 38% of S&P 500 a Concern?
16:15 Gold vs. Bitcoin: The Debasement Trade
17:35 Bitcoin's Surprising Underperformance in 2025
19:43 Should You Own Gold and Bitcoin?
20:38 Phil Rosen's Process: Signal from the Noise
22:03 Opening Bell Daily and Best Ideas Club
24:02 Favorite New York City Spot (A Hard Question!)

YouTube Video UExLT2djMjVoa0d1dENhRkZhSkJpRXhFMTZiWUxtTXJ0dy40QTA3NTU2RkM1QzlCMzYx

How This Bull Market Ends — Phil Rosen’s 2026 Outlook

Mon Feb 2nd, 2026

This week on The Big Skinny, Lou Basenese hands out the ultimate 2025 report card. From the loudest recession warnings and bubble calls to the investments that actually delivered, we break down the best calls, worst misses, and biggest surprises of the year. Lou revisits our top guests, top stock picks, and the predictions that aged like fine wine – and the ones that didn’t. Then we look ahead to 2026, laying out where the next bull markets may emerge and how investors should position now.

- - - - - - - - - - - - - - - - - - -

New to The Big Skinny?

🖥️ Livestream Every Monday @5pm ET 
The Big Skinny LIVE cuts through Wall Street noise so Main Street can actually win — with data, charts, and zero fluff. Whether you’re a seasoned investor or just trying to figure out what the heck the Fed actually does, we break it all down in a way that makes sense — no MBA or nap required. Subscribe and never miss an episode: https://www.youtube.com/@Lou_Basenese

👉 Follow Lou on Social Media:
Twitter: https://x.com/LouBasenese
LinkedIn: https://www.linkedin.com/in/lou-basenese-174821128/

- - - - - - - - - - - - - - - - - - -
Chapters
-----------------------------------
The Rundown
00:00 The Rundown and what this episode covers
03:15 Why year end predictions usually miss the mark

Best Guests of the Year
09:00 Chris Camillo and social arbitrage investing
13:10 Mike Alfred and the AI power bottleneck
18:30 Terawulf CFO Patrick Fleury and AI energy infrastructure
23:40 Jonathan Faison and biotech investing made accessible
29:30 Eric Jackson and retail investor stock ideas
35:10 Beth Kindig and the Nvidia Bull Case

Good and Bad Predictions
41:45 Good predictions that played out
47:30 Bad predictions and what we got wrong

The Skinny Awards
52:20 The First Ever Skinny Awards Begin
53:30 Best Recurring Game or Segment
55:00 Worst Take or Decision of the Year
57:10 Stock Pick of the Year
58:40 Funniest on Air Moment
01:00:10 Fan of the Year and Episode of the Year


#Nvidia #BethKindig #AIStocks #ArtificialIntelligence #Investing #TechStocks #Semiconductors #TheBigSkinny #biotech #MikeAlfred #EricJackson #ChrisCamillo #retailinvestor #retailinvestors

This week on The Big Skinny, Lou Basenese hands out the ultimate 2025 report card. From the loudest recession warnings and bubble calls to the investments that actually delivered, we break down the best calls, worst misses, and biggest surprises of the year. Lou revisits our top guests, top stock picks, and the predictions that aged like fine wine – and the ones that didn’t. Then we look ahead to 2026, laying out where the next bull markets may emerge and how investors should position now.

- - - - - - - - - - - - - - - - - - -

New to The Big Skinny?

🖥️ Livestream Every Monday @5pm ET
The Big Skinny LIVE cuts through Wall Street noise so Main Street can actually win — with data, charts, and zero fluff. Whether you’re a seasoned investor or just trying to figure out what the heck the Fed actually does, we break it all down in a way that makes sense — no MBA or nap required. Subscribe and never miss an episode: https://www.youtube.com/@Lou_Basenese

👉 Follow Lou on Social Media:
Twitter: https://x.com/LouBasenese
LinkedIn: https://www.linkedin.com/in/lou-basenese-174821128/

- - - - - - - - - - - - - - - - - - -
Chapters
-----------------------------------
The Rundown
00:00 The Rundown and what this episode covers
03:15 Why year end predictions usually miss the mark

Best Guests of the Year
09:00 Chris Camillo and social arbitrage investing
13:10 Mike Alfred and the AI power bottleneck
18:30 Terawulf CFO Patrick Fleury and AI energy infrastructure
23:40 Jonathan Faison and biotech investing made accessible
29:30 Eric Jackson and retail investor stock ideas
35:10 Beth Kind and the Nvidia bull case

Good and Bad Predictions
41:45 Good predictions that played out
47:30 Bad predictions and what we got wrong

The Skinny Awards
52:20 The first ever Skinny Awards begin
53:30 Best recurring game segment
55:00 Worst take or decision of the year
57:10 Stock pick of the year
58:40 Funniest on air moment
01:00:10 Fan of the year and episode of the year


#Nvidia #BethKindig #AIStocks #ArtificialIntelligence #Investing #TechStocks #Semiconductors #TheBigSkinny #biotech #MikeAlfred #EricJackson #ChrisCamillo #retailinvestor #retailinvestors

YouTube Video UExLT2djMjVoa0d1dENhRkZhSkJpRXhFMTZiWUxtTXJ0dy4zRDBDOEZDOUM0MDY5NEEz

Survey Says?! The Big Skinny Year in Review (and 2026 Preview)

Tue Dec 16th, 2025

Partner With Us: Reach an Audience of Engaged Investors.

Our audience isn’t just scrolling, they’re investing.

Looking to get in front of investors who actually pay attention? Partner with The Big Skinny. Our fast-growing audience is full of engaged, idea-hungry investors who come to us for fresh takes and smart opportunities. Whether you’re launching something new or looking to build long-term visibility, we help you cut through the noise and get noticed—by the right people.